Genistein

Product name: GenisteinSource: Genista tinctoria Linn, Sophora subprostrala Chun et T.Chen Appearance: Light yellow crystal powder Melting point and solubility: mp297°C-298°C, soluble in DMSO and ethanol, hardly soluble in water Molecular formulation and weight: C15H10O5 270.24 Constructions: Specifications: 98% HPLC Functions: 1. Genistein is an isoflavonoid phytoestrogenic compound found in soybeans, pea pods, and other legumes. The estimated human normal dietary intake of genistein, primarily as glycosides, is 0 to 0.5 mg/kg. Genistein is present in much greater amounts in nutritional supplements. 2. Genistein is carcinogenic in female neonatal mice, inducing endocrine-dependent uterine tumors in a fashion similar to diethylstilbestrol (DES). 3. Genistein is a tyrosine-specific inhibitor of protein kinase activity, blocking the tyrosine-phosphorylation of histone H2B. In adult animals, dietary genistein has chemopreventive effects on breast, prostate, and other endocrine-dependent tumors. 4. Genistein acts as an antioxidant, similar to many other isoflavones, counteracting damaging effects of free radicals in tissues 5. Genistein protects against pro-inflammatory factor-induced vascular endothelial barrier dysfunction and inhibits leukocyte-endothelium interaction, thereby modulating vascular inflammation, a major event in the pathogenesis of atherosclerosis